Author

C. Lyu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Biochemistry· 1 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

S. Chen· 3 shared C. Kang· 2 shared C. Liu· 2 shared J. Guo· 2 shared L. Guo· 2 shared L. Huang· 2 shared R. Wang· 2 shared R. Weigel· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

S. Chen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The Discovery and Characterization of 1,4-Dihydroxy-2-naphthoic Acid Prenyltransferase Involved in the Biosynthesis of Anthraquinones in Rubia cordifolia

C. Liu, R. Wang, S. Wang, T. Chen, C. Lyu, C. Kang, X. Wan, J. Guo, L. Huang, L. Guo

This study identifies and characterizes RcDT1, a prenyltransferase involved in anthraquinone biosynthesis in Rubia cordifolia, and shows its evolutionary origin from the ubiquinone pathway.

bioRxiv · Sep 13, 2023 · PreprintPlant Biology

Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway

C. Lyu, A. K. Bhimani, W. T. Draus, R. Weigel, S. Chen

This study shows that active Gαi/o mutants enhance breast cancer metastasis via the c-Src pathway without affecting primary tumor growth.

bioRxiv · Jan 16, 2023 · PreprintCancer Biology

A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

R. Wang, C. Liu, S. Wang, J. Sun, J. Guo, C. Lyu, C. Kang, X. Wan, L. Shi, J. Wang, L. Huang, L. Guo

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

bioRxiv · Jan 9, 2023 · PreprintBiochemistry

Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse

C. Lyu, Y. Ye, R. J. Weigel, S. Chen

This study shows targeting Gi/o-GPCR signaling eradicates cancer stem cells in HER2+ breast cancer and enhances HER2-targeted therapies to prevent tumor relapse.

bioRxiv · Feb 5, 2022Cancer Biology

The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

C. Lyu, S. Da Vela, Y. K. Al-Hilaly, K. Marshall, R. Thorogate, D. Svergun, L. Serpell, A. Pastore, D. P. Hanger

The paper compares the aggregation propensity of Tau35 to full-length tau, finding Tau35 aggregates more readily and forms denser structures.

bioRxiv · Jul 8, 2021Biophysics

Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy

C. Lyu, Y. Ye, M. Lensing, K.-U. Wagner, R. Weigel, S. Chen

This study shows that blocking Gi/o-GPCR signaling inhibits HER2-driven breast cancer growth and improves HER2-targeted therapy effectiveness.

bioRxiv · Jun 15, 2021Cancer Biology