D. Svergun

The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

The paper compares the aggregation propensity of Tau35 to full-length tau, finding Tau35 aggregates more readily and forms denser structures.

Mechanism of activation and regulation of Deubiquitinase activity in MINDY1 and MINDY2

This paper reveals the mechanism of MINDY1 and MINDY2 deubiquitinase activity, showing how substrate interaction relieves autoinhibition and enables cleavage of K48-linked ubiquitin chains.

Structural role of essential light chains in the apicomplexan glideosome

This study determines the structure of trimeric glideosome subcomplexes in Toxoplasma gondii, revealing conserved interactions and the role of essential light chains in stabilizing myosin A.

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

Molecular basis of F-actin regulation and sarcomere assembly via myotilin

This study reveals the structural dynamics of myotilin and its interaction with F-actin, showing how it stabilizes Z-discs and displaces tropomyosin.

Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms

This study identifies the Btk SH2-kinase interface as critical for activation and shows that targeting it with a repebody inhibits B-cell neoplasms.

Molecular organization of soluble type III secretion system sorting platform complexes

The paper reconstitutes and characterizes the molecular structure of the Salmonella Typhimurium T3SS sorting platform, revealing its stoichiometry and L-shaped conformation.

Molecular mechanism of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX

The paper investigates the interaction between IscX and CyaY in bacterial iron-sulfur cluster assembly, showing IscX modulates CyaY's inhibitory effect on cluster formation.