Characterization of the signalling modalities of prostaglandin E2 receptors EP2 and EP4 reveals crosstalk and a role for microtubules
W. Vleeshouwers, K. van den Dries, S. de Keijzer, B. Joosten, D. S. Lidke, A. Cambi
This study characterizes EP2 and EP4 signaling in myeloid cells, revealing cAMP dynamics and microtubule dependence, with EP4 primarily mediating podosome dissolution.
bioRxiv · Oct 6, 2020Immunology