Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity
A. Ozkan, D. L. Stolley, E. N. K. Cressman, M. McMillin, S. DeMorrow, T. E. Yankeelov, M. N. Rylander
This study shows that HCC chemoresistance to doxorubicin varies with tumor microenvironment stiffness and oxygen levels, mediated by CYP3A4 expression.
bioRxiv · Jan 23, 2021Cancer Biology