M. McMillin

Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain

This paper shows that an avirulent C. difficile strain, ST1-75, protects mice from virulent strain-induced colitis by outcompeting it through rapid amino acid depletion, suggesting potential as a biotherapeutic for CDI prevention.

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

Microbially-catalyzed conjugation of GABA and tyramine to bile acids

The paper identifies bacteria that conjugate GABA and tyramine to bile acids in the human gut and shows these conjugates are present in stool and J-pouch contents.

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

Cirrhosis and Inflammation Regulates CYP3A4 Mediated Chemoresistance in Vascularized Hepatocellular Carcinoma-on-a-chip

This paper develops a vascularized HCC-on-a-chip model to study how cirrhosis and inflammation affect CYP3A4-mediated chemoresistance and treatment efficacy.

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

This study shows that HCC chemoresistance to doxorubicin varies with tumor microenvironment stiffness and oxygen levels, mediated by CYP3A4 expression.