The paper investigates how glucagon hypersecretion in diabetes is linked to misrouting of glucagon and Stathmin-2 towards secretory lysosomes in α-cells.

bioRxiv · Apr 8, 2021Cell Biology

Stathmin-2 Mediates Glucagon Secretion from Pancreatic α-Cells

F. Asadi, S. Dhanvantari

This study identifies stathmin-2 as a novel regulator of glucagon secretion from pancreatic alpha cells by modulating its trafficking through the endosomal-lysosomal system.

bioRxiv · Nov 6, 2019Cell Biology

Plasticity in the glucagon interactome reveals novel proteins that regulate glucagon secretion in alpha TC1-6 cells

F. Asadi, S. Dhanvantari

The paper identifies a dynamic glucagon interactome in alpha TC1-6 cells and shows its plasticity in response to glucose and paracrine stimuli.

bioRxiv · Jul 20, 2018Cell Biology

The Growth Hormone Secretagogue Receptor, Ghrelin and Biochemical Signaling Molecules in Human Heart Failure

R. Sullivan, V. Randhawa, A. Stokes, D. Wu, T. Lalonde, B. Kiaii, L. Luyt, G. Wisenberg, S. Dhanvantari

The paper examines GHSR and ghrelin levels in cardiac tissue from transplant patients to assess their correlation with heart failure markers and function.

bioRxiv · Jul 5, 2018Cell Biology