Local stabilization of subunit-subunit contacts causes global destabilization of Hepatitis B virus capsids
C. Schlicksup, P. Laughlin, S. Dunkelbarger, J. C.-Y. Wang, A. Zlotnick
This study investigates how DBT1, a dibenzothiazapine, affects HBV capsid stability by stabilizing subunit contacts and inducing structural asymmetry, leading to capsid disassembly.
bioRxiv · Jan 24, 2020Biochemistry