Author

A. Zlotnick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

J. C.-Y. Wang· 3 shared C. J. Schlicksup· 2 shared G. Gonzalez-Gutierrez· 2 shared A. J. Patterson· 1 shared B. Bothner· 1 shared B. Tyukodi· 1 shared B. Venkatakrishnan· 1 shared C. Kim· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

J. C.-Y. Wang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

P. M. Laughlin, K. Young, J. C.-Y. Wang, G. Gonzalez-Gutierrez, A. Zlotnick

This study investigates how the ratio of nucleic acid to SARS-CoV-2 N-protein affects liquid-liquid phase separation (LLPS) and finds that a 1:1 ratio maximizes condensate formation.

bioRxiv · Apr 10, 2024Biochemistry

Multiscale Modeling of Hepatitis B Virus Capsid Assembly and its Dimorphism

F. Mohajerani, B. Tyukodi, C. J. Schlicksup, J. A. Hadden-Perilla, A. Zlotnick, M. F. Hagan

This study uses computational models to simulate HBV capsid assembly and identifies factors controlling its dimorphism.

bioRxiv · Feb 23, 2022Biophysics

Core Protein-Directed Antivirals and Importinβ Can Synergistically Disrupt HBV Capsids

C. Kim, L. F. Barnes, C. J. Schlicksup, A. J. Patterson, B. Bothner, M. F. Jarrold, C.-Y. J. Wang, A. Zlotnick

This study shows that HAP12, a CpAM antiviral, synergizes with importinβ to disrupt HBV capsids, revealing an unexpected mechanism of action involving host protein-induced catalysis.

bioRxiv · Aug 16, 2021 · PreprintMicrobiology

Local stabilization of subunit-subunit contacts causes global destabilization of Hepatitis B virus capsids

C. Schlicksup, P. Laughlin, S. Dunkelbarger, J. C.-Y. Wang, A. Zlotnick

This study investigates how DBT1, a dibenzothiazapine, affects HBV capsid stability by stabilizing subunit contacts and inducing structural asymmetry, leading to capsid disassembly.

bioRxiv · Jan 24, 2020Biochemistry

Identification of Chikungunya virus nucleocapsid core assembly modulators

S. E. Jones-Burrage, Z. Tan, L. Li, A. Zlotnick, S. Mukhopadhyay

The paper identifies small molecules that modulate Chikungunya virus nucleocapsid core assembly and inhibit virus production in cell culture.

bioRxiv · Sep 19, 2019 · PreprintMicrobiology

Structural Differences Between the Woodchuck Hepatitis Virus Core Protein in Dimer and Capsid States Indicate Entropic and Conformational Regulation of Assembly

Z. Zhao, J. C.-Y. Wang, G. Gonzalez-Gutierrez, B. Venkatakrishnan, A. Zlotnick

bioRxiv · Jan 4, 2019 · PreprintBiophysics