Isoform-specific functions of Numb in breast cancer progression, metastasis and proteome remodeling.
Y. Zhang, S. E. Dho, C. D. Simpson, K. Othman, A. Bondoc, C. J. McGlade
This study shows that high expression of Numb exon 9-containing isoforms correlates with worse prognosis in breast cancer and promotes progression by reducing integrin surface levels and downstream signaling.
bioRxiv · Feb 1, 2021Cancer Biology