Aberrant DNA repair is a vulnerability in histone H3.3-mutant brain tumors
B. Rondinelli, G. Giacomini, S. Piquet, O. Chevallier, J. Dabin, S.-K. Bai, B. Kim, R. Siddaway, B. Raught, E. Coyaud, C.-M. Shan, R. J. D. Reid, T. Toda, R. Rothstein, T. Wilhelm, , S. E. Polo
The paper identifies aberrant DNA repair as a vulnerability in H3.3-mutant brain tumors, showing that PNKP-mediated repair is specific to mutant cells and offers therapeutic potential.
bioRxiv · Sep 29, 2022 · PreprintCancer Biology