T. Toda

Aberrant DNA repair is a vulnerability in histone H3.3-mutant brain tumors

The paper identifies aberrant DNA repair as a vulnerability in H3.3-mutant brain tumors, showing that PNKP-mediated repair is specific to mutant cells and offers therapeutic potential.

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeast

This study shows that Pkd2, a homolog of human polycystin-2, localizes to the ER and regulates calcium homeostasis in fission yeast, with functional conservation between species.

Proteomic profile of nuclei containing p62-positive inclusions in neuronal intranuclear inclusion disease

The paper identifies 20 proteins increased in nuclei with p62-positive inclusions in NIID using proteomic analysis and confirms their elevated expression via immunofluorescence.

Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast

This study shows that fission yeast uses actin-dependent nuclear displacement during mitosis to avoid a lethal cell division defect.

Autocorrelation-based method to identify disordered rhythm in Parkinsons disease tasks: a novel approach applicable to multimodal devices

This paper introduces an autocorrelation-based method to assess rhythmic irregularity in Parkinson's disease tasks, showing comparable performance to existing approaches.

Effects of dead conspecifics, hunger states, and seasons on the foraging behavior of the purple urchin Heliocidaris crassispina

This study examines how predation cues, hunger states, and seasons affect foraging behavior in purple urchins, finding that starvation reduces predator avoidance and seasonal changes influence activity levels.

Two XMAP215/TOG microtubule polymerases, Alp14 and Dis1, play non-exchangeable, distinct roles in microtubule organisation in fission yeast

This study investigates the distinct functional roles of Alp14 and Dis1, two XMAP215/TOG microtubule polymerases, in fission yeast spindle organization and mitotic progression.

Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast

This study identifies dual roles of Klp9 in fission yeast mitosis, showing it contributes to force generation with Cut7 and structural integrity with Ase1 during anaphase B.

Fission yeast cells overproducing HSET/KIFC1 provides a useful tool for identification and evaluation of human kinesin-14 inhibitors

This paper evaluates HSET inhibitors in fission yeast to identify selective kinesin-14 inhibitors and assess their off-target effects.

Two spatially distinct Kinesin-14 Pkl1 and Klp2 generate collaborative inward forces against Kinesin-5 Cut7 in S. pombe

This study shows how two Kinesin-14 proteins in fission yeast generate inward forces against Kinesin-5 by localizing to different structures, maintaining spindle bipolarity.