Optical measurement of voltage sensing by endogenous ion channel
P. Thapa, R. Stewart, R. J. Sepela, O. Vivas, L. K. Parajuli, M. Lillya, S. Fletcher-Taylor, B. E. Cohen, K. Zito, J. T. Sack
The paper introduces an imaging method to measure conformational changes of endogenous Kv2 voltage sensors in live tissue using a fluorophore-conjugated toxin and statistical modeling.
bioRxiv · Jan 13, 2021Biophysics