Author

P. Thapa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:rat· 2

Frequent Co-Authors

J. T. Sack· 4 shared B. E. Cohen· 2 shared R. J. Sepela· 2 shared R. Stewart· 2 shared A. Ghetti· 1 shared A. N. King· 1 shared A. T. Ton· 1 shared B. Hammock· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

J. T. Sack

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain

P. T. Nguyen, H. M. Nguyen, K. M. Wagner, R. Stewart, V. Singh, P. Thapa, Y.-J. Chen, M. W. Lillya, A. T. Ton, R. Kondo, A. Ghetti, M. W. Pennington, B. Hammock, T. N. Griffith, J. T. Sack, , V. Yarov-Yarovoy

The paper designs potent and selective peptide inhibitors of human NaV1.7 channels using Rosetta, with two peptides showing sub-nanomolar IC50 and high selectivity over other sodium channels.

bioRxiv · Jul 21, 2022Biophysics

The AMIGO1 adhesion protein activates Kv2.1 voltage sensors

R. J. Sepela, R. G. Stewart, L. Valencia, P. Thapa, Z. Wang, B. E. Cohen, J. T. Sack

This study identifies how AMIGO1 modulates Kv2.1 voltage sensor movements and conductance activation by destabilizing the earliest resting state.

bioRxiv · Jun 20, 2021Biophysics

Optical measurement of voltage sensing by endogenous ion channel

P. Thapa, R. Stewart, R. J. Sepela, O. Vivas, L. K. Parajuli, M. Lillya, S. Fletcher-Taylor, B. E. Cohen, K. Zito, J. T. Sack

The paper introduces an imaging method to measure conformational changes of endogenous Kv2 voltage sensors in live tissue using a fluorophore-conjugated toxin and statistical modeling.

bioRxiv · Jan 13, 2021Biophysics

Function of ex vivo stimulated Natural killer T cells from patients with chronic HIV-1 infection

P. Thapa, P. Nehete, H. He, B. Nehete, S. Buchl, L. Bull, H. Lu, R. Arduino, K. J. Sastry, D. Zhou

This study shows that NKT cells from HIV-1 infected patients can be expanded and produce antiviral cytokines when stimulated with ex vivo dendritic cells loaded with alpha-galactosylceramide, except in advanced AIDS patients.

bioRxiv · Nov 5, 2019 · PreprintImmunology

A single-cell reference map for human blood and tissue T cell activation reveals functional states in health and disease

P. A. Szabo, H. M. Levitin, M. Miron, M. E. Snyder, T. Senda, J. Yuan, Y. L. Cheng, E. C. Bush, P. Dogra, P. Thapa, D. L. Farber, P. A. Sims

bioRxiv · Feb 20, 2019 · PreprintImmunology

Organizing neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels

M. Kirmiz, S. Palacio, P. Thapa, A. N. King, J. T. Sack, J. Trimmer

The paper shows Kv2 ion channels organize ER-PM junctions independently of their ion-conducting function, conserved across species and distinct from their role in neuronal excitability.

bioRxiv · Apr 6, 2018Cell Biology