The Development of Resistance to an Inhibitor of a Cellular Protein Reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1
E. G. Viktorova, S. Gabaglio, S. Moghimi, A. Zimina, B. G. Wynn, E. Sztul, G. A. Belov
This study shows that mutations in the enterovirus protein 2C confer resistance to BFA by enhancing its interaction with activated Arf1, suggesting a GBF1-independent replication mechanism.
bioRxiv · May 9, 2023 · PreprintMicrobiology