Active Enterohepatic Cycling is Not Required for the Choleretic Actions of 24-norUrsodeoxycholic Acid in Mice
J. Li, J. K. Truong, K. Pachura, A. Rao, S. Gambeer, C. D. Fuchs, S. J. Karpen, M. J. Trauner, P. A. Dawson
This study shows that norUDCA induces bile flow and bicarbonate secretion in mice without requiring ASBT or OST, suggesting these transporters are not directly involved in its choleretic actions.
bioRxiv · Mar 6, 2021 · PreprintCell Biology