Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs
N. Joisten, D. Walzik, A. Schenk, A. J. Metcalfe, S. Belen, K. Schaaf, D. Jacko, S. Gehlert, P. Spiliopoulou, A.-M. Garzinsky, M. Thevis, L. Rappelt, L. Donath, S. G. Meuth, W. Bloch, P. Zimmer
This study shows acute exercise increases kynurenine pathway metabolites and activates the AHR in human PBMCs, linking exercise to immune modulation via this pathway.
bioRxiv · Jan 17, 2024 · PreprintImmunology