Author

P. Spiliopoulou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

S. Spear· 3 shared H. B. Mirza· 2 shared I. Garner· 2 shared N. Iyer· 2 shared R. Brown· 2 shared A. J. Metcalfe· 1 shared A. P. Costa-Pereira· 1 shared A. P. Siskos· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

S. Spear

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs

N. Joisten, D. Walzik, A. Schenk, A. J. Metcalfe, S. Belen, K. Schaaf, D. Jacko, S. Gehlert, P. Spiliopoulou, A.-M. Garzinsky, M. Thevis, L. Rappelt, L. Donath, S. G. Meuth, W. Bloch, P. Zimmer

This study shows acute exercise increases kynurenine pathway metabolites and activates the AHR in human PBMCs, linking exercise to immune modulation via this pathway.

bioRxiv · Jan 17, 2024 · PreprintImmunology

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

I. Dye, S. Laing, I. Garner, H. B. Mirza, N. Iyer, N. Brady, P. Spiliopoulou, S. Spear, J. Robinson, F. Fiorentino, M. J. Fuchter, D. J. Murphy, I. J. McNeish, R. Brown

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

bioRxiv · Oct 18, 2023 · PreprintCancer Biology

Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma

S. Spear, O. Le Saux, H. B. Mirza, K. Tyson, J. Bickel, F. Grundland Freile, A. P. Siskos, C. Balcells, J. B. Walton, C. Woodman, D. P. Ennis, N. Iyer, C. Aguirre Hernandez, Y. Xu, P. Spiliopoulou, , I. A. McNeish

This study identifies HMOX1-expressing omental macrophages as a therapeutic target and biomarker for poor prognosis ovarian high-grade serous carcinoma.

bioRxiv · Jul 18, 2023 · PreprintCancer Biology

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

P. Spiliopoulou, S. Spear, H. Mirza, I. Garner, L. Mcgarry, F. Grundland-Freile, Z. Cheng, D. Ennis, S. McNamara, M. Natoli, S. Mason, K. Blyth, P. Adams, P. Roxburgh, M. Fuchter, , I. McNeish

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

bioRxiv · May 9, 2021Cancer Biology