Kinetics and efficacy of antibody drug conjugates in 3D tumour models
C. S. P. Chaundler, H. Lu, R. Fu, N. Wang, H. Lou, G. Serrano de Almeida, L. M. Hadi, E. Aboagye, S. Ghaem-Maghami
This study evaluates ADC efficacy in 3D tumor models, finding that spheroids are less sensitive to ADCs than monolayers, but ADCs can fully penetrate within 24h.
bioRxiv · Feb 14, 2023 · PreprintBiochemistry