Structural Basis of the Transmembrane Domain Dimerization in the Activation Mechanism of TrkA by NGF
M. L. Franco, K. Nadezhdin, K. Mineev, S. Goncharuk, A. Arseniev, M. Vilar
This study identifies structural determinants of TrkA dimerization and activation by NGF, revealing the role of the transmembrane domain and juxtamembrane region in receptor activation.
bioRxiv · Oct 23, 2019Biochemistry