Author

M. L. Franco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Vilar· 5 shared A. S. Arseniev· 2 shared K. S. Mineev· 2 shared S. A. Goncharuk· 2 shared A. Arseniev· 1 shared A. Becker· 1 shared A. Benito-Martinez· 1 shared A. Cattaneo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

M. Vilar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

K. M. Zoltowska, U. Das, S. Lismont, T. Enzlein, M. Maesako, M. C. Houser, D. Gomes Moreira, M. L. Franco, B. Ozcan, D. Karachentsev, A. Becker, C. Hopf, M. Vilar, O. Berezovska, W. Mobley, L. Chavez-Gutierrez

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

bioRxiv · Aug 2, 2023Biochemistry

Structural Basis for the transmembrane signaling and antidepressant-induced activation of the receptor tyrosine kinase TrkB

E. F. Kot, S. A. Goncharuk, M. L. Franco, A. S. Arseniev, A. Benito-Martinez, M. Costa, A. Cattaneo, M. Vilar, K. S. Mineev

This study determines the structure of the TrkB transmembrane domain using NMR and shows how fluoxetine activates the receptor by binding to it.

bioRxiv · Jun 6, 2023Biochemistry

Identification of a guanine-specific pocket in the protein N of SARS-CoV-2

R. Ciges-Tomas, M. L. Franco, M. Vilar

The paper identifies a guanine-specific pocket in the SARS-CoV-2 N protein that may be targeted for viral assembly inhibitors.

bioRxiv · Jun 21, 2022Biophysics

Neurotrophin signaling is modulated by specific transmembrane domain interactions

M. L. Franco, K. D. Nadezhdin, T. P. Light, S. A. Goncharuk, A. Soler-Lopez, F. Ahmed, K. S. Mineev, K. Hristova, A. S. Arseniev, M. Vilar

The paper identifies and characterizes the direct interaction between TrkA and p75 through their transmembrane domains, showing its role in TrkA activation and cell differentiation.

bioRxiv · May 24, 2021 · PreprintBiochemistry

Structural Basis of the Transmembrane Domain Dimerization in the Activation Mechanism of TrkA by NGF

M. L. Franco, K. Nadezhdin, K. Mineev, S. Goncharuk, A. Arseniev, M. Vilar

This study identifies structural determinants of TrkA dimerization and activation by NGF, revealing the role of the transmembrane domain and juxtamembrane region in receptor activation.

bioRxiv · Oct 23, 2019Biochemistry