Author

S. Grüschow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

J. S. Athukoralage· 3 shared M. F. White· 3 shared S. Graham· 3 shared C. M. Czekster· 1 shared C. Rouillon· 1 shared S. McQuarrie· 1 shared T. Hoogeboom· 1 shared T. M. Gloster· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

J. S. Athukoralage

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3 papers

Recent·Most cited

Tetramerisation of the CRISPR ring nuclease Csx3 facilitates cyclic oligoadenylate cleavage

S. Graham, S. Grüschow, T. M. Gloster, S. McQuarrie, M. F. White, J. S. Athukoralage

The paper identifies Csx3 as a ring nuclease that degrades cyclic tetra-adenylate (cA4), revealing its role in removing cOA molecules after viral infection.

bioRxiv · Apr 28, 2020Biochemistry

The dynamic interplay of host and viral enzymes in type III CRISPR-mediated cyclic nucleotide signalling

J. S. Athukoralage, S. Grüschow, S. Graham, C. M. Czekster, C. Rouillon, M. F. White

The paper examines how host and viral enzymes regulate cyclic nucleotide levels and infection outcomes in type III CRISPR systems.

bioRxiv · Feb 12, 2020Biochemistry

Cyclic oligoadenylate signalling mediates Mycobacterium tuberculosis CRISPR defence

S. Grüschow, J. S. Athukoralage, S. Graham, T. Hoogeboom, M. F. White

This study shows that Mycobacterium tuberculosis uses a type III-A CRISPR system with a cyclic hexa-adenylate (cA6) signalling pathway and the Csm6 ribonuclease for immunity against mobile genetic elements, rather than DNA cleavage.

bioRxiv · Jun 12, 2019Biochemistry