J. S. Athukoralage

The paper identifies Csx3 as a ring nuclease that degrades cyclic tetra-adenylate (cA4), revealing its role in removing cOA molecules after viral infection.

The paper describes a fusion protein combining a ribonuclease and a ring nuclease to regulate cOA signaling in type III CRISPR systems, ensuring a time-limited immune response.

The paper examines how host and viral enzymes regulate cyclic nucleotide levels and infection outcomes in type III CRISPR systems.

This study identifies a viral anti-CRISPR enzyme that degrades cyclic tetra-adenylate, neutralizing type III CRISPR immunity in bacteria and archaea.

This study shows that Mycobacterium tuberculosis uses a type III-A CRISPR system with a cyclic hexa-adenylate (cA6) signalling pathway and the Csm6 ribonuclease for immunity against mobile genetic elements, rather than DNA cleavage.

The paper identifies TTHB144 as a self-limiting CRISPR ribonuclease that degrades its cyclic oligoadenylate activator, providing a mechanism to terminate RNA degradation after viral infection.

The paper identifies a Ring nuclease that degrades cyclic oligoadenylate (cOA) to deactivate Type III CRISPR ribonucleases and terminate the antiviral state.