Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling.
G. Leon, P. A. Klavina, A. M. Rehill, S. Chomanahalli Basavarajappa, J. S. O'Donnell, S. Hussey, P. T. Walsh, R. J. S. Preston
This study identifies TF-mediated thrombogenicity in colitogenic CD4+ T cells and shows APC signalling reduces their procoagulant activity in IBD.
bioRxiv · Apr 16, 2024Immunology