Nucleolar TFIIE plays a role in ribosomal biogenesis and performance
T. Phan, P. Maity, C. Ludwig, L. Streit, J. Michaelis, K. Scharffetter-Kochanek, S. Iben
This study identifies TFIIE's role in ribosomal RNA synthesis and shows that mutations impair ribosomal biogenesis, leading to proteostasis loss and TTD symptoms.
bioRxiv · Dec 16, 2020Cell Biology