Tubulinopathy mutations in TUBA1A that disrupt neuronal morphogenesis and migration override XMAP215/Stu2 regulation of microtubule dynamics
K. J. Hoff, J. E. Aiken, M. A. Gutierrez, S. J. Franco, J. K. Moore
This study investigates how TUBA1A mutations V409I and V409A affect neuronal migration and microtubule dynamics, finding that they disrupt microtubule regulation and lead to brain malformations.
bioRxiv · Dec 6, 2021Cell Biology