J. K. Moore

Selective regulation of kinesin-5 function by β-tubulin carboxy-terminal tails

This study identifies a molecular mechanism by which β-tubulin tails selectively regulate kinesin-5 motors, ensuring proper mitotic spindle function in budding yeast.

Quantifying yeast microtubules and spindles using the Toolkit for Automated Microtubule Tracking (TAMiT)

The paper introduces TAMiT, an automated tool for tracking fluorescent microtubules in yeast cells, showing it reliably detects and measures microtubule dynamics even at low signal-to-noise ratios.

Asymmetric requirement for α-tubulin over β-tubulin

The paper investigates how cells regulate α- and β-tubulin levels to maintain microtubule function and prevent toxicity from excess β-tubulin monomers.

Tubulinopathy mutations in TUBA1A that disrupt neuronal morphogenesis and migration override XMAP215/Stu2 regulation of microtubule dynamics

This study investigates how TUBA1A mutations V409I and V409A affect neuronal migration and microtubule dynamics, finding that they disrupt microtubule regulation and lead to brain malformations.

Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone

This study investigates how Ase1 domains regulate spindle elongation during anaphase by controlling midzone formation and Bim1 recruitment.

Systemic immune response profiling with SYLARAS implicates a role for CD45R/B220+ CD8+ T cells in glioblastoma immunology

The paper introduces SYLARAS, a tool for immune response profiling, and shows CD45R/B220+ CD8+ T cells are depleted in circulation and accumulate in glioblastoma tumors in mice, with similar cells found in human GBM.