Author

S. J. Keppie

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Cell Biology· 1

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Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

A. Wall· 1 shared C. J. Philp· 1 shared C. McLean· 1 shared C. P. Winlove· 1 shared G. E. Pavlovskaya· 1 shared H. K. Graham· 1 shared J. C. Mansfield· 1 shared M. J. Sherratt· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

A. Wall

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1 paper

Recent·Most cited

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

S. J. Keppie, J. C. Mansfield, X. Tang, C. J. Philp, H. K. Graham, P. Önnerfjord, A. Wall, C. McLean, C. P. Winlove, M. J. Sherratt, G. E. Pavlovskaya, T. L. Vincent

This paper identifies a novel repair mechanism in cartilage where aggrecan-dependent sodium flux, triggered by mechanical injury, releases growth factors that promote tissue regeneration, which is impaired in osteoarthritis.

bioRxiv · Jan 31, 2021Cell Biology