Author

M. J. Sherratt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

D. F. Holmes· 3 shared B. Derby· 2 shared C. R. Saville· 2 shared E. Emmerson· 2 shared J. Swift· 2 shared M. J. Hardman· 2 shared A. Adamson· 1 shared A. E. Canfield· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

D. F. Holmes

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Novel in-silico predicted matrikines are differential mediators of in vitro and in vivo cellular metabolism

N. Jariwala, M. Ozols, A. Eckersley, B. Mambwe, R. E. B. Watson, L. Zeef, A. Gilmore, L. Debelle, M. Bell, E. J. Bradley, Y. Doush, C. Courage, R. Leroux, O. Peschard, P. Mondon, , M. J. Sherratt

The paper presents an in silico to in vivo pipeline to identify novel matrikines that differentially influence cellular metabolism in vitro and in vivo.

bioRxiv · Mar 17, 2023 · PreprintCell Biology

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding site

A. R. Godwin, J. Thomson, D. F. Holmes, C. S. Adamo, G. Sengle, M. J. Sherratt, A. M. Roseman, C. Baldock

The paper reveals the cryo-EM structure of fibrillin microfibrils and shows how mutations disrupt TGFβ signaling by blocking LTBP-1 interaction through long-range structural effects.

bioRxiv · Aug 26, 2022 · PreprintBiochemistry

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

S. J. Keppie, J. C. Mansfield, X. Tang, C. J. Philp, H. K. Graham, P. Önnerfjord, A. Wall, C. McLean, C. P. Winlove, M. J. Sherratt, G. E. Pavlovskaya, T. L. Vincent

This paper identifies a novel repair mechanism in cartilage where aggrecan-dependent sodium flux, triggered by mechanical injury, releases growth factors that promote tissue regeneration, which is impaired in osteoarthritis.

bioRxiv · Jan 31, 2021Cell Biology

Loss of PKCα increases arterial medial calcification in a uremic mouse model of chronic kidney disease

S. J. Borland, C. Facchi, J. Behnsen, A. Adamson, N. E. Humphreys, P. J. Withers, M. J. Sherratt, S. E. Francis, K. Brennan, N. Ashton, A. E. Canfield

This study shows that PKC loss increases uremia-induced arterial medial calcification in mice, suggesting PKC/TGF-β signaling as a therapeutic target.

bioRxiv · May 20, 2020 · PreprintCell Biology

Estrogen mediates acute elastic fibre homeostasis in skin

C. R. Saville, D. F. Holmes, J. Swift, B. Derby, E. Emmerson, M. J. Hardman, M. J. Sherratt

This study shows that estrogen deficiency reduces skin elasticity and elastic fibre abundance, which can be reversed by estrogen replacement.

bioRxiv · Aug 8, 2019 · PreprintBiophysics

Distinct matrix composition and mechanics in aged and estrogen-deficient mouse skin

C. R. Saville, V. Mallikarjun, D. F. Holmes, E. Emmerson, B. Derby, J. Swift, M. J. Sherratt, M. J. Hardman

This study examines how aging and estrogen deficiency affect skin matrix composition and mechanics in mice, finding contrasting effects on tensile strength and collagen levels.

bioRxiv · Mar 8, 2019 · PreprintBiophysics