S. J. Maerkl

Targeting protein-ligand neosurfaces using a generalizable deep learning approach

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.

A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical survey and monitoring

This paper introduces a rapid plant DNA extraction method using microneedle patches, validated against Qiagen extractions, showing comparable sequencing results in just 1 minute.

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

The paper systematically analyzes low-affinity transcription factor binding site clusters in vitro and in vivo, showing they can achieve substantial occupancies and drive transcriptional activation.

High-throughput single-cell TCR - pMHC dissociation rate measurements performed by an autonomous microfluidic cellular processing unit

The paper develops a microfluidic device to measure TCR-pMHC dissociation rates in single cells and demonstrates its high-throughput capability.

Nature-inspired Circular-economy Recycling (NaCRe) for Proteins: Proof of Concept

This study demonstrates a method to recycle proteins into new functional proteins using a cell-free system, aligning with circular-economy principles.

A Microfluidic Module For Real-Time Generation Of Complex Multi-Molecule Temporal Concentration Profiles

This paper introduces a microfluidic module that generates complex, dynamic concentration profiles of multiple molecules using pulse-width modulation, demonstrating precise control over a wide range of concentrations and molecular weights.