R. Mezzenga

Surface crosslinking of virus-like particles increases resistance to proteases, low pH and mechanical stress for mucosal applications

This study enhances the stability of virus-like particles (VLPs) against environmental stressors by surface crosslinking, without affecting their vaccine function.

Nanoscale clustering by O-antigen-Secretory Immunoglobulin-A binding limits outer membrane diffusion by encaging individual Salmonella cells

The paper shows SIgA binding to Salmonella O-antigen nanoscale crosslinks the outer membrane, leading to biased inheritance and accelerated IgA escape through phase-variation.

Integrative solution structure of a PTBP1-viral IRES complex reveals strong compaction and ordering with residual conformational flexibility

The paper determines the solution structure of a PTBP1-viral IRES complex using integrative modeling, revealing compaction, ordering, and residual flexibility essential for IRES-mediated translation.

Trapping virus-loaded aerosols using granular protein nanofibrils and iron oxyhydroxides nanoparticles

This paper introduces an environmentally-friendly aerosol filter made from whey protein nanofibrils and iron oxyhydroxides nanoparticles that efficiently traps various viruses.

The interface of condensates of the hnRNPA1 low complexity domain promotes formation of amyloid fibrils

This study shows that amyloid fibrils form at the interface of hnRNPA1 condensates, not uniformly within them, and that surfactants can inhibit this process.

A conserved mechanism regulates reversible amyloids via pH-sensing regions

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.

Nature-inspired Circular-economy Recycling (NaCRe) for Proteins: Proof of Concept

This study demonstrates a method to recycle proteins into new functional proteins using a cell-free system, aligning with circular-economy principles.

Elucidating the mechanism of cyclodextrins in the treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin

This study investigates the mechanism of crosslinked 2-hydroxypropyl-β-cyclodextrin (HPβCD) in treating Niemann-Pick Disease Type C and evaluates its in vivo efficacy with MRIg-FUS to enhance brain penetration.