B. E. Correia

Targeting protein-ligand neosurfaces using a generalizable deep learning approach

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.

Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses

The paper reports cryo-EM structures of foamy virus Env in pre- and post-fusion states, revealing structural similarity to paramyxovirus F proteins and suggesting an evolutionary link.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

Assessing and enhancing foldability in designed proteins

This study develops methods to assess and improve foldability in designed proteins, significantly enhancing catalytic efficiency and stability.

The Physiological Landscape and Specificity of Antibody Repertoires

This study analyzes antibody repertoires across multiple lymphoid organs in immunized mice, finding that strong humoral responses lead to consolidated, overlapping B-cell clones and a uniform but redundant physiological landscape.