High CD44 expression identifies rare chemoresistant leukemic cells endowed with enhanced E-Selectin binding in T-ALL
J. Calvo, I. Naguibneva, A. Kypraios, B. Uzan, B. Gaillard, L. Bellenger, L. Renou, C. Antoniewski, H. Lapillone, A. Petit, P. Ballerini, S. J. Mancini, T. Marchand, J.-F. Peyron, F. Pflumio
The paper identifies a chemoresistant leukemic stem cell population in T-ALL with high CD44 expression and enhanced E-selectin binding, associated with poor prognosis and relapse.
bioRxiv · Dec 20, 2023 · PreprintCancer Biology