S. J. Sturla

Single-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide

This paper introduces O6-MeG-seq, a method to map O6-methylguanine at single-nucleotide resolution, and shows MGMT does not preferentially repair O6-MeG based on sequence context or chromatin state.

Chemical screening of food-related chemicals for human fatty liver risk: Combining high content imaging of cellular responses with in vitro to in vivo extrapolation

This study combines high-content imaging and computational models to assess food-related chemicals' risk for fatty liver disease by extrapolating human oral equivalent doses from in vitro data.