MLC Seq: De novo sequencing of full-length tRNA isoforms by mass ladder complementation
X. Yuan, Y. Su, X. Zhang, S. J. Turkel, S. Shi, X. Wang, E.-J. Choi, W. Wu, H. Liu, R. Viner, J. J. Russo, W. Li, X. Bao, Q. Chen, S. Zhang
This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.
bioRxiv · May 22, 2021Biochemistry