X. Yuan

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

This study evaluates a multivalent mRNA vaccine against SARS-CoV-2 variants in mice, showing broad protection against multiple strains.

Neurophysiological Features of STN LFP underlying Sleep Fragmentation in Parkinson's Disease

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes

This study uses microfluidic impedance cytometry to analyze the cellular state changes in Hela cells treated with paclitaxel and vinblastine, showing distinct electrical parameter shifts during mitotic arrest and apoptosis.

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

Protein subcellular relocalization and function of duplicated flagellar calcium binding protein genes in honey bee trypanosomatid parasite

This study investigates the subcellular localization and function of duplicated FCaBP genes in L. passim, showing their role in flagellar structure and function through interactions with the BBSome complex.

Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture

This study investigates how carotenoid assembly affects quinone diffusion and the structure of the reaction center-light harvesting complex in Roseiflexus castenholzii.

Aspartyl protease in the secretome of honey bee trypanosomatid parasite is essential for the efficient infection of host

The paper identifies the exoproteome of the honey bee trypanosomatid parasite Lotmaria passim and shows that an aspartyl protease is essential for efficient infection of the host.

An oligosaccharide analog exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

Evolutionary history of metazoan TMEM16 family

This study investigates the evolutionary history of the TMEM16 family in metazoans, identifying subfamily origins, gene duplications, and functional adaptations through genomic analysis.

Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1

This study identifies myeloid HIF1A as a cardio-protective factor during ischemia and reperfusion, mediated by netrin-1 induction in neutrophils.

Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

Multinuclear MRI reveals early efficacy of stem cell therapy in stroke

This study uses multinuclear MRI to assess early efficacy of stem cell therapy in stroke by monitoring sodium homeostasis and lactate levels in treated animals.

DWV 3C protease uncovers the diverse catalytic triad in insect RNA viruses

This study characterizes the structure and function of DWV 3C protease, revealing a diverse catalytic triad among insect RNA viruses and potential inhibitors for controlling DWV infection.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

Use of eVLP-based vaccine candidates to broaden immunity against SARS-CoV-2 variants

This study evaluates eVLP-based vaccine candidates against SARS-CoV-2 variants, showing that a trivalent vaccine induces broader immunity compared to single-variant vaccines.

Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA viruses

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

WWP1 deficiency protects from cardiac remodeling induced by simulated microgravity

This study shows that WWP1 deficiency protects against cardiac remodeling and function decline caused by simulated microgravity in mice.

Heme oxygenase-2 (HO-2) binds and buffers labile heme, which is largely oxidized, in human embryonic kidney cells

This study shows HO-2 binds and buffers oxidized labile heme in HEK293 cells, regulating heme homeostasis by controlling bioavailability rather than degrading heme under non-stress conditions.

MLC Seq: De novo sequencing of full-length tRNA isoforms by mass ladder complementation

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

A novel type of IRES having variable numbers of eIF4E-binding site and synergistic effect in RNA2 of WYMV isolates

The paper identifies a novel IRES in WYMV RNA2 with variable eIF4E-binding sites and synergistic effects that enhance IRES activity.

Improving localization precision via restricting biomolecule confined stochastic motion in SMLM

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

Fusobacterium nucleatum facilitates cetuximab resistance in colorectal cancer via the PI3K/AKT and JAK/STAT3 pathways

Reporting quality of trend analyses published in leading medicine and oncology journals during 2008-2018

This study assesses the reporting quality of trend analyses in leading medicine and oncology journals from 2008-2018, finding moderate quality with room for improvement.