LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein
J. Shilts, T. M. Crozier, A. Teixeira-Silva, I. Gabaev, E. J. D. Greenwood, S. J. Watson, B. M. Ortmann, C. M. Gawden-Bone, T. Pauzaite, M. Hoffmann, J. A. Nathan, S. Pöhlmann, P. J. Lehner, G. J. Wright
The paper identifies LRRC15 as a novel host factor that interacts with SARS-CoV-2 spike protein, distinct from ACE2 and other known receptors, and shows it modulates viral infection.
bioRxiv · Sep 25, 2021Biochemistry