Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms
B. G. Budaitis, S. Jariwala, L. Rao, D. Sept, K. Verhey, A. Gennerich
This study shows that pathogenic mutations in KIF1A reduce force generation through allosteric effects, impacting neuronal transport and contributing to neurodevelopmental disorders.
bioRxiv · Sep 3, 2020Biophysics