Author

A. Gennerich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. Rao· 6 shared X. Liu· 3 shared A. B. Asenjo· 1 shared A. I. Son· 1 shared A. J. Lam· 1 shared B. G. Budaitis· 1 shared D. Sept· 1 shared D. W. Nowakowski· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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6 shared papersBiophysics

L. Rao

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes

A. Gennerich, X. Liu, L. Rao, W. Qiu

This study investigates the force generation and motility of Kinesin-14 motors HSET and KlpA, revealing they are non-processive motors with load-dependent power strokes and cooperative behavior.

bioRxiv · Jun 9, 2023 · PreprintBiophysics

Cryo-EM Unveils the Processivity Mechanism of Kinesin KIF1A and the Impact of its Pathogenic Variant P305L

M. P. M. H. Benoit, L. Rao, A. B. Asenjo, A. Gennerich, H. J. Sosa

The paper presents high-resolution cryo-EM structures of KIF1A-microtubule complexes, revealing the mechanism of processivity and the impact of the P305L mutation on microtubule binding.

bioRxiv · Feb 2, 2023 · PreprintBiochemistry

Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

L. Rao, P. Li, X. Liu, Q. Wang, A. I. Son, A. Gennerich, J. Shih-Hwa Liu, X. Fu

This study identifies DCX and JIP3 as neural-specific regulators that counteract each other in dynein-mediated retrograde trafficking by modulating dynein-microtubule binding and motor complex composition.

bioRxiv · Aug 10, 2022 · PreprintCell Biology

A Highly Conserved 310-Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health.

A. J. Lam, L. Rao, Y. Anazawa, K. Okada, K. Chiba, S. Niwa, A. Gennerich, D. W. Nowakowski, R. J. McKenney

This study identifies a conserved 310-helix in KIF1A critical for motor function and human health, showing that the P305L mutation disrupts microtubule association and motor performance.

bioRxiv · Sep 22, 2020Biophysics

The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

A. Gennerich, X. Liu, L. Rao

This study investigates the role of AAA4 ATPase in cytoplasmic dynein's mechanochemical cycle using single-molecule techniques, showing its critical role in enabling motion through interactions with AAA1 and AAA3.

bioRxiv · Sep 20, 2020Biophysics

Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms

B. G. Budaitis, S. Jariwala, L. Rao, D. Sept, K. Verhey, A. Gennerich

This study shows that pathogenic mutations in KIF1A reduce force generation through allosteric effects, impacting neuronal transport and contributing to neurodevelopmental disorders.

bioRxiv · Sep 3, 2020Biophysics