Author

D. Sept

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Gennerich· 1 shared A. I. Nesvizhskii· 1 shared A. J. Hunt· 1 shared A. L. Solon· 1 shared A. Mordovanakis· 1 shared A. R. Paredez· 1 shared A. Soranno· 1 shared B. G. Budaitis· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

A. Gennerich

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein

O. L. Mooren, M. D. Stuchell-Brereton, P. McConnell, C. Yan, E. M. Wilkerson, D. Goldfarb, J. A. Cooper, D. Sept, A. Soranno

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

bioRxiv · Aug 16, 2023Biochemistry

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding

A. L. Solon, Z. Tan, K. L. Schutt, L. Jepsen, S. E. Haynes, A. I. Nesvizhskii, D. Sept, J. Stumpff, R. Ohi, M. A. Cianfrocco

This study determines the structural mechanism by which KIFBP remodels kinesin motors to block microtubule-binding, revealing a 2-pronged inhibition strategy.

bioRxiv · Jun 2, 2021Cell Biology

Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement Through Allosteric Mechanisms

B. G. Budaitis, S. Jariwala, L. Rao, D. Sept, K. Verhey, A. Gennerich

This study shows that pathogenic mutations in KIF1A reduce force generation through allosteric effects, impacting neuronal transport and contributing to neurodevelopmental disorders.

bioRxiv · Sep 3, 2020Biophysics

Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

Y. M. Yamashita, C. Chen, A. Mordovanakis, A. J. Hunt, M. Mayer, R. Cummings, D. Sept

The paper identifies a novel mechanism where the cytokine receptor Dome interacts with Eb1 to regulate spindle orientation in Drosophila GSCs, linking cell polarity to fate without involving the JAK-STAT pathway.

bioRxiv · Dec 4, 2017Cell Biology

14-3-3 Negatively Regulates Actin Filament Formation In The Deep Branching Eukaryote Giardia lamblia

J. Krtkova, J. Xu, M. Lalle, M. Steele-Ogus, G. C. M. Alas, D. Sept, A. R. Paredez

This study shows that 14-3-3 negatively regulates actin filament formation in Giardia lamblia by interacting with actin and modulating its phosphorylation state.

bioRxiv · May 26, 2017Cell Biology