Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant
S. K. Gersing, Y. Wang, M. Gronbaek-Thygesen, C. Kampmeyer, L. Clausen, C. Andreasson, A. Stein, K. Lindorff-Larsen, R. Hartmann-Petersen
This study investigates the degradation pathway of a disease-linked ASPA variant, finding it is degraded via the proteasome and dependent on Hsp70 and Hsp110.
bioRxiv · Sep 4, 2020Biochemistry