Identification of glucose-independent metabolic pathways associated with anti-proliferative effect of metformin, their coordinate derangement with cMyc downregulation and reversibility in liver cancer cells.
This study identifies glucose-independent metabolic pathways and cMyc downregulation as contributors to metformin's anti-proliferative effect in liver cancer cells, showing reversibility upon drug withdrawal.
bioRxiv · Aug 4, 2023 · PreprintCancer Biology