Reclassification of SLC22 Transporters: Analysis of OAT, OCT, OCTN, and other Family Members Reveals 8 Functional Subgroups
D. C. Engelhart, J. Granados, S. K. Nigam, D. Shi, M. H. Saier, M. E. Baker
This paper reclassifies SLC22 transporters into 8 functional subgroups using GWAS, in vivo models, and in vitro assays, revealing shared substrate specificity and subgroup associations.
bioRxiv · Dec 23, 2019Pharmacology & Toxicology