M. E. Baker

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone

This study compares the transcriptional activation of two human mineralocorticoid receptor variants by aldosterone, finding increased activation in MR-988 with KCSW in the DNA-binding domain.

Novel Evolution of the Mineralocorticoid Receptor in Humans compared to Chimpanzees, Gorillas and Orangutans

This study identifies novel human mineralocorticoid receptor variants not found in chimpanzees, gorillas, or orangutans, suggesting evolutionary divergence in MR function.

Reduced steroid activation of elephant shark GR and MR after inserting four amino acids from the DBD of lamprey corticoid receptor-1

The paper inserts four amino acids from lamprey CR1 into elephant shark MR and GR to test if their absence reduces steroid transcriptional activation, finding that the insert decreases activation.

N-terminal Domain Influences Steroid Activation of the Atlantic Sea Lamprey Corticoid Receptor

This study identifies and characterizes the N-terminal domain of the Atlantic sea lamprey corticoid receptor, showing its critical role in steroid-mediated transcriptional activation and promoter-specific regulation.

Cloning of Nine Glucocorticoid Receptor Isoforms from the Slender African lungfish (Protopterus dolloi)

The paper reports the cloning of nine GR isoforms from slender African lungfish after failed attempts using existing primers, and explains the reasons for the initial failure.

Aldosterone and Dexamethasone Activate African Lungfish Mineralocorticoid Receptor: Increased Activation After Removal of the Amino-Terminal Domain

The paper investigates the activation of the African lungfish mineralocorticoid receptor by various steroids, finding that corticosteroids and glucocorticoids can activate it, with the N-terminal domain repressing activation.

Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspective

This study compares steroid activation of elephant shark and human progesterone receptors, revealing evolutionary changes in specificity and response to RU486.

N-terminal Domain Regulates Steroid Activation of Elephant Shark Glucocorticoid and Mineralocorticoid Receptors

The paper shows that the N-terminal domain of elephant shark GR regulates steroid activation, with functional divergence from MR.

Reclassification of SLC22 Transporters: Analysis of OAT, OCT, OCTN, and other Family Members Reveals 8 Functional Subgroups

This paper reclassifies SLC22 transporters into 8 functional subgroups using GWAS, in vivo models, and in vitro assays, revealing shared substrate specificity and subgroup associations.

Transcriptional Activation of Elephant Shark Mineralocorticoid Receptor by Corticosteroids, Progestins and Spironolactone

The paper analyzes the activation of elephant shark mineralocorticoid receptor by corticosteroids and progesterone, finding that aldosterone is absent in cartilaginous fishes and progesterone activates shark MR but not human MR.

Evolution of human, chicken, alligator, frog and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity

The paper examines steroid activation of mineralocorticoid receptors (MRs) across species, finding differences in agonist activity and regulatory mechanisms between full-length and truncated MRs.

The promiscuous estrogen receptor: evolution of physiological estrogens and response to phytochemicals and endocrine disruptors

This paper examines the structural diversity of physiological estrogens and their response to synthetic and plant-derived chemicals, proposing evolutionary origins for estrogen receptor ligands.

Evolution of the Mineralocorticoid Receptor: Sequence, Structure and Function

This study investigates the evolution of mineralocorticoid receptor (MR) selectivity for 3-ketosteroids by analyzing sequence, structure, and transcriptional activation data across vertebrates.