Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization
S.-M. Kim, Y. Liu, Y. Wang, S. Karkashon, A. Lewis-Ballester, S.-R. Yeh, M. A. Correia
This paper identifies the exosite of TDO as the molecular mechanism enabling L-Trp-mediated protein stabilization through ubiquitin-dependent degradation regulation.
bioRxiv · Oct 4, 2019 · PreprintBiochemistry