M. A. Correia

In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization

This study identifies p62-IκBα interaction hotspots using in-cell crosslinking and proteomics, revealing p62 stabilizes IκBα to limit NF-κB activation and prevent liver inflammation.

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/ Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.

This study shows that genetic ablation of gp78/AMFR in mice stabilizes hepatic P450 enzymes, enhancing their drug metabolism and potentially affecting drug response and toxicity.

Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization

This paper identifies the exosite of TDO as the molecular mechanism enabling L-Trp-mediated protein stabilization through ubiquitin-dependent degradation regulation.

Mitochondrial dysfunction is signaled to the integrated stress response by OMA1, DELE1 and HRI

The paper identifies OMA1, DELE1, and HRI as a pathway that relays mitochondrial dysfunction to the integrated stress response, showing its role in activating eIF2 kinase activity and potential therapeutic relevance.

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

This study identifies a novel mechanism of NF-κB activation through IκB sequestration into insoluble aggregates along with aggregation-prone proteins in MDB-inducing models.