S.-M. Kim

Development and Biophysical Characterization of a Humanized FSH-Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra-High Concentration

This paper develops a stable, high-concentration formulation of a humanized FSH-blocking antibody and validates its physicochemical and thermal stability.

Acquired epithelial WNT secretion drives niche independence of developing gastric cancer

The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

The Hepcidin Regulator Erythroferrone is a New Member of the Erythropoiesis-Iron-Bone Circuitry

This study identifies erythroferrone as a regulator of the erythropoiesis-iron-bone circuitry, showing its role in modulating BMP signaling and preventing bone loss during erythropoiesis.

Single-cell Transcriptome of Bronchoalveolar Lavage Fluid Reveals Dynamic Change of Macrophages During SARS-CoV-2 Infection in Ferrets

This study uses single-cell RNA sequencing to track macrophage dynamics in SARS-CoV-2-infected ferrets over time, revealing distinct subpopulations and functional changes.

Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/ Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.

This study shows that genetic ablation of gp78/AMFR in mice stabilizes hepatic P450 enzymes, enhancing their drug metabolism and potentially affecting drug response and toxicity.

Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization

This paper identifies the exosite of TDO as the molecular mechanism enabling L-Trp-mediated protein stabilization through ubiquitin-dependent degradation regulation.