Putative rapid-acting antidepressant nitrous oxide ("laughing gas") evokes rebound emergence of slow EEG oscillations during which TrkB signaling is induced
S. Kohtala, W. Theilmann, M. Rosenholm, P. Kiuru, S. Uusitalo, K. Järventausta, A. Yli-Hankala, J. Yli-Kauhaluoma, H.-K. Wigren, T. Rantamäki
This study shows that nitrous oxide induces rebound slow EEG oscillations and TrkB signaling changes after withdrawal, similar to ketamine and ECT, suggesting a shared mechanism for rapid antidepressant effects.
Molecular Neurobiology · Oct 4, 2018Peer-reviewedPharmacology & Toxicology