Inhibition of the JAK/STAT pathway with baricitinib reduces the multiple organ dysfunction caused by hemorrhagic shock in rats
N. M. Patel, D. Collotta, E. Aimaretti, G. Ferreira Alves, S. Kröller, S. M. Coldewey, M. Collino, C. Thiemermann
This study shows that baricitinib reduces multiple organ dysfunction in hemorrhagic shock rats by inhibiting JAK/STAT, NF-κB, and NLRP3 pathways.
bioRxiv · Jan 13, 2022Pharmacology & Toxicology