Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
J. Waaler, L. Mygland, A. Tveita, M. F. Strand, N. T. Solberg, P. Angell Olsen, K. Lund, S. Alam Brinch, M. Lycke, E. Dybing, V. Nygaard, S. L. Boe, K.-M. Heintz, E. Hovig, C. Hammarstrom, , S. Krauss
This study shows that tankyrase inhibition makes melanoma more responsive to PD-1 checkpoint blockade in mouse models by reducing WNT/β-catenin and YAP signaling.
bioRxiv · Jan 22, 2019Cancer Biology