S. Krauss

Simultaneous LC-MS determination of glucose regulatory peptides secreted by stem cell-derived islet organoids

The paper develops an RPLC-MS/MS method to simultaneously measure insulin, somatostatin-14, and glucagon from stem cell-derived islet organoids on an organ-on-chip platform, showing functional hormone secretion.

Acoustic wave-induced stroboscopic optical mechanotyping of adherent cells

This study introduces a technique to measure the mechanical properties of living cells using acoustic waves and imaging, demonstrating its ability to mechanotype cell populations with sub-cellular resolution.

Mass Spectrometry Reveals that Oxysterols are Secreted from Non-Alcoholic Fatty Liver Disease Induced Organoids

The paper uses mass spectrometry to show that liver organoids secrete oxysterols, with 26-hydroxycholesterol being elevated in steatotic organoids and potentially acting as a biomarker for NAFLD.

Pump-less, recirculating organ-on-a-chip (rOoC) platform

This paper introduces a pump-less organ-on-a-chip platform that enables directional flow through gravity and microfluidic design, demonstrating endothelialisation and hepatic organoid integration.

Horizontal transfer of bacteriocin biosynthesis genes requires metabolic adaptation to improve compound production and cellular fitness

This study shows that transferring bacteriocin biosynthesis genes between Staphylococcus aureus strains requires metabolic adaptation to enhance compound production and cellular fitness.

Adipose-derived stromal cells preserve pancreatic islet function in a transplantable 3D bioprinted scaffold

This study shows that adipose-derived stromal cells improve islet survival and function in a 3D bioprinted scaffold, offering a potential cell therapy for diabetes.

Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian Influenza A subtypes among North American wild reservoir species

This study estimates interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild birds using genomic sequences, finding host diversity and ecology influence spread patterns.

The adenoviral E1B-55k protein present in HEK293 cells mediates abnormal accumulation of key WNT signaling proteins in large cytoplasmic aggregates.

This study shows that the adenoviral E1B-55k protein in HEK293 cells causes abnormal accumulation of WNT signaling proteins into cytoplasmic aggregates, affecting their function.

"Organoid-in-a-column" coupled on-line with liquid chromatography-mass spectrometry

This paper demonstrates the integration of liver organoids with liquid chromatography-mass spectrometry for on-line drug metabolism analysis.

Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies

This study demonstrates the use of electromembrane extraction (EME) combined with mass spectrometry to monitor drug metabolism in liver organoids.

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models

This study shows that tankyrase inhibition makes melanoma more responsive to PD-1 checkpoint blockade in mouse models by reducing WNT/β-catenin and YAP signaling.

Seasonality dynamics of avian influenza occurrences in Central and West Africa

This study examines the seasonality of avian influenza in Central and West Africa, finding higher detection rates during rainy seasons and linking AI presence to environmental factors.